InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CARD14

Summary

InnateDB Gene

IDBG-71483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CARD14

Gene Name

caspase recruitment domain family, member 14

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000141527

Encoded Proteins

IDBP-71485

caspase recruitment domain family, member 14

IDBP-759514

IDBP-761832

IDBP-761228

IDBP-759558

IDBP-759613

IDBP-758678

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:80169992-80209331

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000344227	ENSP00000344549
ENST00000576785	ENSP00000461447
ENST00000573882	ENSP00000458715
ENST00000571450	ENSP00000460405
ENST00000571861
ENST00000573754
ENST00000575500	ENSP00000460883
ENST00000570421	ENSP00000461806
ENST00000575465	ENSP00000459244
ENST00000572838
ENST00000573489
ENST00000571427
ENST00000574148
ENST00000575666

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0050700	CARD domain binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006915	apoptotic process
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000013483

View Gene Order

ENSBTAG00000015261

Not yet available

Cross-References

SwissProt

Q9BXL6

TrEMBL

I3L1Z7 I3L4Q8

UniProt Splice Variant

Entrez Gene

79092

UniGene

Hs.696253 Hs.738929 Hs.739340

RefSeq

NM_001257970 NM_024110

HUGO

HGNC:16446

OMIM

607211

CCDS

CCDS11768 CCDS58605

HPRD

06235

IMGT

EMBL

AC087741 AF322642 AY032927 BC001326 BC018142 EU652409

GenPept

AAG53403 AAH01326 AAH18142 AAK54453 ACF49506

RNA Seq Atlas

79092