Version 5.4
Homo sapiens Protein: PLEKHF1
Summary
InnateDB Protein IDBP-762237.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHF1
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000466292
InnateDB Gene IDBG-41768 (PLEKHF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0046872 metal ion binding
GO:0070273 phosphatidylinositol-4-phosphate binding
Biological Process
GO:0006915 apoptotic process
GO:0007032 endosome organization
GO:0010508 positive regulation of autophagy
GO:0016050 vesicle organization
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0010008 endosome membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000306 FYVE zinc finger
IPR001849 Pleckstrin homology domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF01363
PF00169
PRINTS
PIRSF
SMART SM00064
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96S99
PhosphoSite PhosphoSite-Q96S99
TrEMBL K7ELB8
UniProt Splice Variant
Entrez Gene 79156
UniGene Hs.466383
RefSeq XP_005259313
HUGO HGNC:20764
OMIM 615200
CCDS CCDS12417
HPRD 15146
IMGT
EMBL AC010512 AC010644 AF434818 AK027758 AK301616 AY037145 BC002744
GenPept AAH02744 AAK67626 AAL30773 BAB55349 BAG63101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca