Version 5.4
Homo sapiens Protein: KIAA1267
Summary
InnateDB Protein IDBP-762542.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIAA1267
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000461812
InnateDB Gene IDBG-55420 (KIAA1267)
Protein Structure
UniProt Annotation
Function As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269PubMed:20018852, ECO:0000269PubMed:22547026}.
Subcellular Localization Nucleus {ECO:0000269PubMed:20018852}.
Disease Associations
Tissue Specificity Expressed in the brain. {ECO:0000269PubMed:11641718}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
Biological Process
GO:0006325 chromatin organization
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0071339 MLL1 complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z3B3
PhosphoSite PhosphoSite-Q7Z3B3
TrEMBL I3L243
UniProt Splice Variant
Entrez Gene 284058
UniGene Hs.700846
RefSeq XP_005257289
HUGO HGNC:24565
OMIM 612452
CCDS CCDS11503
HPRD 11254
IMGT
EMBL AB033093 AC217773 AK291259 AL117476 AL137317 BC035892 BC098376 BX538006 BX648760 CH471233 CR936218
GenPept AAH35892 AAH98376 BAA86581 BAF83948 CAB55949 CAB70694 CAD97958 CAH10565 EAW93576 EAW93577

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca