Homo sapiens Gene: KIAA1267

Summary
InnateDB Gene IDBG-55420.6
Last Modified 2013-04-25   [Report errors or provide feedback]
Gene Symbol KIAA1267
Gene Name KAT8 regulatory NSL complex subunit 1
Synonyms CENP-36; hMSL1v1; KDVS; KIAA1267; MSL1v1; NSL1
Species Homo sapiens
Ensembl Gene ENSG00000120071
Encoded Proteins
IDBP-55422 KIAA1267
IDBP-243534 KIAA1267
IDBP-380176 KIAA1267
IDBP-759779
IDBP-762542
IDBP-760856
IDBP-757856
IDBP-761115
IDBP-763256
Entrez Gene
Summary This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 44107282-44302733
Strand Reverse strand
Band q21.31
Transcripts
ENST00000262419  ENSP00000262419
ENST00000393476  ENSP00000377117
ENST00000432791  ENSP00000387393
ENST00000572904  ENSP00000461484
ENST00000573286 
ENST00000576248 
ENST00000576870 
ENST00000572218 
ENST00000574590  ENSP00000461812
ENST00000571698  ENSP00000459330
ENST00000575318  ENSP00000461299
ENST00000574655  ENSP00000459359
ENST00000574963 
ENST00000577114 
ENST00000572679 
ENST00000576739  ENSP00000459627
ENST00000573682 
ENST00000576137 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein‑Protein  40
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
Biological Process
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0071339 MLL1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000018412 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000012564 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q7Z3B3 
TrEMBL E9PCT4 I3L233 I3L243 I3L4J3
UniProt Splice Variant
Entrez Gene 284058 
UniGene Hs.618377 Hs.619321 Hs.630341 Hs.648744 Hs.690905 Hs.700846
RefSeq NM_001193465  NM_001193466  NM_015443 
HUGO 24565 
OMIM 612452
CCDS CCDS11503 
HPRD 11254
IMGT
EMBL AB033093 AC217773 AK291259 AL117476 AL137317 BC035892 BC098376 BX538006 BX648760 CR936218
GenPept AAH35892  AAH98376  BAA86581  BAF83948  CAB55949  CAB70694  CAD97958  CAH10565 
ImmGen KIAA1267 (murine) 
RNA Seq Atlas 284058