InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX21

Summary

InnateDB Protein

IDBP-76285.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX21

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 21

Synonyms

GUA; GURDB; RH-II/GU; RH-II/GuA;

Species

Homo sapiens

Ensembl Protein

ENSP00000346120

InnateDB Gene

IDBG-76283 (DDX21)

Protein Structure

UniProt Annotation

Function

Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing. {ECO:0000269PubMed:11823437, ECO:0000269PubMed:14559904}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:8614622}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	118 [view]
Protein-Protein	115 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006200	ATP catabolic process
GO:0009615	response to virus
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DEAD/DEAH box helicase domain
IPR012562 GUCT
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04851
PF00270
PF08152

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NR30