InnateDB Protein
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IDBP-763208.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLK5
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000468376
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InnateDB Gene
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IDBG-14733 (PLK5)
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Protein Structure
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Function |
Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation. {ECO:0000269PubMed:21245385}.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:21245385}.
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Disease Associations |
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Tissue Specificity |
Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated cells, such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the seminal gland, Kupffer cells and some hepatocytes in the liver, and some cells in the germinal center of lymph nodes (at protein level). {ECO:0000269PubMed:21245385}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0004672
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protein kinase activity
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GO:0005524
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ATP binding
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GO:0016772
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transferase activity, transferring phosphorus-containing groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000719
Protein kinase domain
IPR011009
Protein kinase-like domain
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PFAM |
PF00069
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q496M5
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PhosphoSite |
PhosphoSite-Q496M5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
126520
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UniGene |
Hs.195352
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RefSeq |
NP_001230008
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HUGO |
HGNC:27001
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OMIM |
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CCDS |
CCDS59328
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HPRD |
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IMGT |
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EMBL |
AC027307
AK054808
BC100791
DQ424898
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GenPept |
ABD83663
BAG51426
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