InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCF1

Summary

InnateDB Protein

IDBP-76325.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCF1

Protein Name

ATP-binding cassette, sub-family F (GCN20), member 1

Synonyms

ABC27; ABC50;

Species

Homo sapiens

Ensembl Protein

ENSP00000365728

InnateDB Gene

IDBG-76321 (ABCF1)

Protein Structure

UniProt Annotation

Function

Isoform 2 is required for efficient Cap- and IRES- mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269PubMed:19570978}.

Subcellular Localization

Isoform 2: Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:9790762}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0008494	translation activator activity
GO:0016887	ATPase activity
GO:0043022	ribosome binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006412	translation
GO:0006413	translational initiation
GO:0006954	inflammatory response
GO:0045727	positive regulation of translation