Version 5.4
Homo sapiens Gene: ABCF1
Summary
InnateDB Gene IDBG-76321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCF1
Gene Name ATP-binding cassette, sub-family F (GCN20), member 1
Synonyms ABC27; ABC50
Species Homo sapiens
Ensembl Gene ENSG00000204574
Encoded Proteins
IDBP-76325
ATP-binding cassette, sub-family F (GCN20), member 1
IDBP-76327
ATP-binding cassette, sub-family F (GCN20), member 1
IDBP-368828
ATP-binding cassette, sub-family F (GCN20), member 1
IDBP-601912
ATP-binding cassette, sub-family F (GCN20), member 1
IDBP-588282
ATP-binding cassette, sub-family F (GCN20), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:30571376-30597179
Strand Forward strand
Band p21.33
Transcripts
ENST00000376545 ENSP00000365728
ENST00000326195 ENSP00000313603
ENST00000441867 ENSP00000405512
ENST00000468958 ENSP00000440893
ENST00000475993 ENSP00000445100
ENST00000479542
ENST00000542772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0008494 translation activator activity
GO:0016887 ATPase activity
GO:0043022 ribosome binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006412 translation
GO:0006413 translational initiation
GO:0006954 inflammatory response
GO:0045727 positive regulation of translation
Cellular Component
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0016020 membrane
GO:0042788 polysomal ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038762
View Gene Order
ENSBTAG00000006927
Not yet available
Cross-References
SwissProt Q8NE71
TrEMBL F5GYK6 Q2L6I2 Q5STZ8
UniProt Splice Variant
Entrez Gene 23
UniGene Hs.655285
RefSeq NM_001025091 NM_001090
HUGO HGNC:70
OMIM 603429
CCDS CCDS34380 CCDS34381
HPRD
IMGT
EMBL AB088096 AB103602 AB202093 AF027302 AL662800 AL662825 AL832430 BA000025 BC034488 BC112923 BX000357 BX119957 BX248518 BX927220 CH471081 CR388372 CR753328 CR759778 CR847863
GenPept AAC70891 AAH34488 AAI12924 BAB63325 BAC54928 BAE78612 BAF31263 CAH10648 CAI17836 CAI17837 CAI18158 CAI18159 CAI18562 CAI18563 CAM25907 CAM26017 CAQ07804 CAQ07873 CAQ09058 CAQ09401 CAQ10059 EAX03300 EAX03301
RNA Seq Atlas 102723826 23

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca