InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCR3

Summary

InnateDB Protein

IDBP-76337.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCR3

Protein Name

chemokine (C-X-C motif) receptor 3

Synonyms

CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R; Mig-R; MigR;

Species

Homo sapiens

Ensembl Protein

ENSP00000362795

InnateDB Gene

IDBG-76333 (CXCR3)

Protein Structure

UniProt Annotation

Function

Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. {ECO:0000269PubMed:12782716}.Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP- mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. {ECO:0000269PubMed:12782716}.Isoform 3: Mediates the activity of CXCL11.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000269PubMed:12782716}; Multi-pass membrane protein {ECO:0000269PubMed:12782716}.Isoform 2: Cell membrane {ECO:0000269PubMed:12782716}; Multi-pass membrane protein {ECO:0000269PubMed:12782716}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level). {ECO:0000269PubMed:12782716, ECO:0000269PubMed:23121557}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0016494	C-X-C chemokine receptor activity
GO:0019956	chemokine binding
GO:0019958	C-X-C chemokine binding

Biological Process

GO:0001525	angiogenesis
GO:0001937	negative regulation of endothelial cell proliferation
GO:0002685	regulation of leukocyte migration
GO:0006915	apoptotic process
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008284	positive regulation of cell proliferation
GO:0010818	T cell chemotaxis
GO:0016525	negative regulation of angiogenesis
GO:0019722	calcium-mediated signaling
GO:0030816	positive regulation of cAMP metabolic process
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050921	positive regulation of chemotaxis
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0071954	chemokine (C-C motif) ligand 11 production
GO:1900118	negative regulation of execution phase of apoptosis
GO:1900119	positive regulation of execution phase of apoptosis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR004070 CXC chemokine receptor 3
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00241
PR00237
PR00657
PR00645
PR01532

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49682