InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCR3

Summary

InnateDB Gene

IDBG-76333.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCR3

Gene Name

chemokine (C-X-C motif) receptor 3

Synonyms

CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R; Mig-R; MigR

Species

Homo sapiens

Ensembl Gene

ENSG00000186810

Encoded Proteins

IDBP-76335

chemokine (C-X-C motif) receptor 3

IDBP-76337

chemokine (C-X-C motif) receptor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21518789

CXCR3 expression on recruited peritoneal macrophages and granulocytes increases following sepsis, and deletion of CXCR3 significantly increases mortality to a septic challenge in neonatal mice. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21518789

[Mus musculus] Cxcr3 expression on recruited peritoneal macrophages and granulocytes increases following sepsis, and deletion of Cxcr3 significantly increases mortality to a septic challenge in neonatal mice.

PMID 24130498

[Mus musculus] Inflammatory monocyte activation status, as measured by dual production of TNF-alpha and IL-12, was severely impaired in Cxcr3(-/-) mice. Deletion of Cxcr3 in mice resulted in selective loss of ability to control T. gondii infection specifically in the lamina propria compartment.

PMID 25466888

[Mus musculus] Cxcr3 expression in innate CD8+ T cells defines protective antibacterial and cancer immunity upon Il15 stimulation.

PMID 26595890

[Mus musculus] A Cxcr3-dependent innate antiviral pathway operates at epithelial surfaces to induce chemokines and neutrophil activity prior to the induction of interferons.

Entrez Gene

Summary

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:71615916-71618517

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000373693	ENSP00000362797
ENST00000373691	ENSP00000362795

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0016494	C-X-C chemokine receptor activity
GO:0019956	chemokine binding
GO:0019958	C-X-C chemokine binding

Biological Process

GO:0001525	angiogenesis
GO:0001937	negative regulation of endothelial cell proliferation
GO:0002685	regulation of leukocyte migration
GO:0006915	apoptotic process
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008284	positive regulation of cell proliferation
GO:0010818	T cell chemotaxis
GO:0016525	negative regulation of angiogenesis
GO:0019722	calcium-mediated signaling
GO:0030816	positive regulation of cAMP metabolic process
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050921	positive regulation of chemotaxis
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0071954	chemokine (C-C motif) ligand 11 production
GO:1900118	negative regulation of execution phase of apoptosis
GO:1900119	positive regulation of execution phase of apoptosis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane