InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPHK1

Summary

InnateDB Protein

IDBP-763471.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPHK1

Protein Name

Synonyms

SPHK;

Species

Homo sapiens

Ensembl Protein

ENSP00000465726

InnateDB Gene

IDBG-69650 (SPHK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008481	sphinganine kinase activity
GO:0017050	D-erythro-sphingosine kinase activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0006457	protein folding
GO:0006665	sphingolipid metabolic process
GO:0006670	sphingosine metabolic process
GO:0007165	signal transduction
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
GO:0016310	phosphorylation
GO:0019722	calcium-mediated signaling
GO:0030148	sphingolipid biosynthetic process
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0031398	positive regulation of protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0043066	negative regulation of apoptotic process
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045931	positive regulation of mitotic cell cycle
GO:0045987	positive regulation of smooth muscle contraction
GO:0046521	sphingoid catabolic process
GO:0046834	lipid phosphorylation
GO:0048146	positive regulation of fibroblast proliferation
GO:0051084	'de novo' posttranslational protein folding
GO:0051092	positive regulation of NF-kappaB transcription factor activity