InnateDB Protein
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IDBP-763811.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SRSF1
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Protein Name
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Synonyms
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ASF; SF2; SF2p33; SFRS1; SRp30a;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000463223
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InnateDB Gene
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IDBG-60601 (SRSF1)
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Protein Structure
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Function |
Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'- CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269PubMed:8139654}.
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Subcellular Localization |
Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 171 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
171
[view]
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Protein-Protein |
166
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q07955
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PhosphoSite |
PhosphoSite-Q07955
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TrEMBL |
Q59FA2
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UniProt Splice Variant |
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Entrez Gene |
6426
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UniGene |
Hs.712821
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RefSeq |
XP_006722075
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HUGO |
HGNC:10780
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OMIM |
600812
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CCDS |
CCDS58580
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HPRD |
02887
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IMGT |
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EMBL |
AB062124
AB209558
AC015813
AK312781
BC010264
BC033785
CH471109
M69040
M72709
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GenPept |
AAA03476
AAA35564
AAA35565
AAH10264
AAH33785
BAB93456
BAD92795
BAG35644
EAW94485
EAW94486
EAW94491
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