InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIN4

Summary

InnateDB Protein

IDBP-76431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIN4

Protein Name

protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)

Synonyms

EPVH; PAR14; PAR17;

Species

Homo sapiens

Ensembl Protein

ENSP00000362773

InnateDB Gene

IDBG-76429 (PIN4)

Protein Structure

UniProt Annotation

Function

Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. {ECO:0000269PubMed:19369196}.Isoform 2 binds to double-stranded DNA. {ECO:0000269PubMed:19369196}.

Subcellular Localization

Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.Isoform 2: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N- terminal domain that functions as non-cleavable mitochondrial targeting peptide.

Disease Associations

Tissue Specificity

Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed. {ECO:0000269PubMed:10100858, ECO:0000269PubMed:10364457, ECO:0000269PubMed:16522211}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003681	bent DNA binding
GO:0003690	double-stranded DNA binding
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0016853	isomerase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006364	rRNA processing
GO:0006457	protein folding

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005759	mitochondrial matrix
GO:0005819	spindle
GO:0030684	preribosome
GO:0070062	extracellular vesicular exosome