Version 5.4
Homo sapiens Gene: PIN4
Summary
InnateDB Gene IDBG-76429.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIN4
Gene Name protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
Synonyms EPVH; PAR14; PAR17
Species Homo sapiens
Ensembl Gene ENSG00000102309
Encoded Proteins
IDBP-76431
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
IDBP-76433
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
IDBP-485161
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
IDBP-375670
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
IDBP-375683
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
IDBP-375687
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
IDBP-483733
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:72181353-72302926
Strand Forward strand
Band q13.1
Transcripts
ENST00000373669 ENSP00000362773
ENST00000218432 ENSP00000218432
ENST00000373662 ENSP00000421392
ENST00000423432 ENSP00000409154
ENST00000446576 ENSP00000402330
ENST00000439980 ENSP00000394066
ENST00000496835 ENSP00000421676
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003681 bent DNA binding
GO:0003690 double-stranded DNA binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0016853 isomerase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006364 rRNA processing
GO:0006457 protein folding
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005819 spindle
GO:0030684 preribosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079480
View Gene Order
ENSBTAG00000047376
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655623
RefSeq NM_001170747 NM_006223
HUGO
OMIM
CCDS CCDS14417 CCDS55447
HPRD 02219
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca