Version 5.4
Homo sapiens Protein: PAK4
Summary
InnateDB Protein IDBP-764372.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAK4
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000471157
InnateDB Gene IDBG-49980 (PAK4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 33 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006928 cellular component movement
GO:0007010 cytoskeleton organization
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0016049 cell growth
GO:0016477 cell migration
GO:0023014 signal transduction by phosphorylation
Cellular Component
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID
InterPro IPR000095 CRIB domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00786
PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00285
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O96013
PhosphoSite PhosphoSite-O96013
TrEMBL M0R3G6
UniProt Splice Variant
Entrez Gene 10298
UniGene Hs.20447
RefSeq NP_001014835
HUGO HGNC:16059
OMIM 605451
CCDS CCDS33019
HPRD 05675
IMGT
EMBL AB032968 AC011443 AF005046 AJ011855 AK074728 AK294586 AK300632 AL834236 BC002921 BC011368 BC025282 BC034511 CH471126
GenPept AAD01210 AAH02921 AAH11368 AAH25282 AAH34511 BAA86456 BAC11166 BAG57777 BAG62322 CAA09820 CAD38914 EAW56861 EAW56863 EAW56865

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca