Version 5.4
Homo sapiens Protein: VEZF1
Summary
InnateDB Protein IDBP-764408.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VEZF1
Protein Name
Synonyms DB1; ZNF161;
Species Homo sapiens
Ensembl Protein ENSP00000462337
InnateDB Gene IDBG-60556 (VEZF1)
Protein Structure
UniProt Annotation
Function Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. {ECO:0000269PubMed:8035792}.
Subcellular Localization Nucleus {ECO:0000269PubMed:8035792}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Highest levels in skeletal muscle and kidney. {ECO:0000269PubMed:8035792}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001885 endothelial cell development
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006968 cellular defense response
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14119
PhosphoSite PhosphoSite-Q14119
TrEMBL
UniProt Splice Variant
Entrez Gene 7716
UniGene Hs.714434
RefSeq NP_009077
HUGO HGNC:12949
OMIM 606747
CCDS CCDS32687
HPRD 08416
IMGT
EMBL AC015813 D28118
GenPept BAA05663

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca