Version 5.4
Homo sapiens Protein: WIPF2
Summary
InnateDB Protein IDBP-764582.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WIPF2
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000462350
InnateDB Gene IDBG-47317 (WIPF2)
Protein Structure
UniProt Annotation
Function Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269PubMed:11829459, ECO:0000269PubMed:12213210}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:11829459, ECO:0000269PubMed:12213210}. Note=Localized to stress fibers and bundles of actin filaments.
Disease Associations
Tissue Specificity Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta. {ECO:0000269PubMed:11829459, ECO:0000269PubMed:12213210}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR003124 WH2 domain
PFAM PF02205
PRINTS
PIRSF
SMART SM00246
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TF74
PhosphoSite PhosphoSite-Q8TF74
TrEMBL J3QKM5
UniProt Splice Variant
Entrez Gene 147179
UniGene Hs.731598
RefSeq
HUGO HGNC:30923
OMIM 609692
CCDS CCDS11364
HPRD 18304
IMGT
EMBL AB043786 AC068669 AC080112 AF370396 AJ431177 AK289578 AK289779 AK290301 AK315836 AL834239 BC065551
GenPept AAH65551 AAQ15232 BAB85113 BAF82267 BAF82468 BAF82990 BAF98727 CAD24007 CAH56360

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca