InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLD1

Summary

InnateDB Protein

IDBP-764735.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLD1

Protein Name

Synonyms

CDC2; CRCS10; MDPL; POLD;

Species

Homo sapiens

Ensembl Protein

ENSP00000473052

InnateDB Gene

IDBG-64392 (POLD1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	59 [view]
Protein-Protein	57 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0000731	DNA synthesis involved in DNA repair
GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006284	base-excision repair
GO:0006287	base-excision repair, gap-filling
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0007346	regulation of mitotic cell cycle
GO:0009411	response to UV
GO:0032201	telomere maintenance via semi-conservative replication
GO:0043137	DNA replication, removal of RNA primer
GO:0044281	small molecule metabolic process
GO:0045004	DNA replication proofreading
GO:0055089	fatty acid homeostasis
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016235	aggresome
GO:0043625	delta DNA polymerase complex

Protein Structure and Domains

PDB ID

InterPro

IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
IPR006172 DNA-directed DNA polymerase, family B
IPR012337 Ribonuclease H-like domain

PFAM

PF03104
PF00136

PRINTS

PR00106

PIRSF

SMART

SM00486

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt