InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: POLD1

Summary

InnateDB Gene

IDBG-64392.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLD1

Gene Name

polymerase (DNA directed), delta 1, catalytic subunit

Synonyms

CDC2; CRCS10; MDPL; POLD

Species

Homo sapiens

Ensembl Gene

ENSG00000062822

Encoded Proteins

IDBP-383794

polymerase (DNA directed), delta 1, catalytic subunit 125kDa

IDBP-764258

IDBP-765323

IDBP-764735

IDBP-762141

IDBP-762236

IDBP-762419

IDBP-760296

IDBP-765291

IDBP-812796

polymerase (DNA directed), delta 1, catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3\' to 5\' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:50384204-50418018

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000440232	ENSP00000406046
ENST00000596425	ENSP00000470426
ENST00000593407	ENSP00000469115
ENST00000599857	ENSP00000473052
ENST00000593887	ENSP00000472607
ENST00000596648
ENST00000596221
ENST00000601098	ENSP00000472600
ENST00000597963
ENST00000600746
ENST00000593981	ENSP00000469308
ENST00000600859	ENSP00000470726
ENST00000595904	ENSP00000472445
ENST00000613923	ENSP00000481858

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	59 [view]
Protein-Protein	57 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0000731	DNA synthesis involved in DNA repair
GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006284	base-excision repair
GO:0006287	base-excision repair, gap-filling
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0007346	regulation of mitotic cell cycle
GO:0009411	response to UV
GO:0032201	telomere maintenance via semi-conservative replication
GO:0043137	DNA replication, removal of RNA primer
GO:0044281	small molecule metabolic process
GO:0045004	DNA replication proofreading
GO:0055089	fatty acid homeostasis
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016235	aggresome
GO:0043625	delta DNA polymerase complex