Version 5.4
Homo sapiens Protein: GPS1
Summary
InnateDB Protein IDBP-764796.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPS1
Protein Name
Synonyms COPS1; CSN1;
Species Homo sapiens
Ensembl Protein ENSP00000462265
InnateDB Gene IDBG-73152 (GPS1)
Protein Structure
UniProt Annotation
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269PubMed:11285227, ECO:0000269PubMed:11337588, ECO:0000269PubMed:12628923, ECO:0000269PubMed:12732143, ECO:0000269PubMed:9535219}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:9535219}. Nucleus {ECO:0000269PubMed:9535219}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:8943324}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 81 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0007049 cell cycle
GO:0007254 JNK cascade
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
Protein Structure and Domains
PDB ID
InterPro IPR000717 Proteasome component (PCI) domain
IPR019585 26S proteasome, regulatory subunit Rpn7
PFAM PF01399
PF10602
PRINTS
PIRSF
SMART SM00088
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13098
PhosphoSite PhosphoSite-Q13098
TrEMBL J3QS88
UniProt Splice Variant
Entrez Gene 2873
UniGene Hs.268530
RefSeq XP_005256417
HUGO HGNC:4549
OMIM 601934
CCDS
HPRD 15991
IMGT
EMBL AC135056 AK093283 BC000155 BC064503 BT009834 CH471099 U20285
GenPept AAC50906 AAH00155 AAH64503 AAP88836 BAC04120 EAW89742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca