InnateDB Protein
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IDBP-76483.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SRGN
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Protein Name
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serglycin
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Synonyms
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PPG; PRG; PRG1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000242465
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InnateDB Gene
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IDBG-76481 (SRGN)
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Protein Structure
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Function |
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269PubMed:11911826, ECO:0000269PubMed:16420477, ECO:0000269PubMed:16870619}.
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Subcellular Localization |
Cytoplasmic granule {ECO:0000250}. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007455
Serglycin
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PFAM |
PF04360
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P10124
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5552
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UniGene |
Hs.732466
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RefSeq |
NP_002718
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HUGO |
HGNC:9361
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OMIM |
177040
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CCDS |
CCDS7285
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HPRD |
01513
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IMGT |
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EMBL |
AK311873
AL442635
BC015516
CH471083
J03223
M33649
M33650
M33651
M90058
X12765
X17042
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GenPept |
AAA60179
AAA60322
AAH15516
BAG34814
CAA31255
CAA34900
CAH71778
EAW54309
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