Version 5.4
Homo sapiens Gene: SRGN
Summary
InnateDB Gene IDBG-76481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRGN
Gene Name serglycin
Synonyms PPG; PRG; PRG1
Species Homo sapiens
Ensembl Gene ENSG00000122862
Encoded Proteins
IDBP-76483
serglycin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:69088106-69104811
Strand Forward strand
Band q22.1
Transcripts
ENST00000242465 ENSP00000242465
ENST00000462445
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0002576 platelet degranulation
GO:0007596 blood coagulation
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0016485 protein processing
GO:0030168 platelet activation
GO:0030502 negative regulation of bone mineralization
GO:0031214 biomineral tissue development
GO:0033364 mast cell secretory granule organization
GO:0033371 T cell secretory granule organization
GO:0033373 maintenance of protease location in mast cell secretory granule
GO:0033382 maintenance of granzyme B location in T cell secretory granule
GO:0050710 negative regulation of cytokine secretion
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0031093 platelet alpha granule lumen
GO:0042588 zymogen granule
GO:0042629 mast cell granule
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020077
View Gene Order
Pathways
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592951 Hs.732466
RefSeq NM_002727
HUGO
OMIM
CCDS CCDS7285
HPRD 01513
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca