Version 5.4
Homo sapiens Protein: SCIMP
Summary
InnateDB Protein IDBP-764918.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCIMP
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000459605
InnateDB Gene IDBG-21257 (SCIMP)
Protein Structure
UniProt Annotation
Function Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. {ECO:0000269PubMed:21930792}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269PubMed:21930792}; Lipid-anchor {ECO:0000269PubMed:21930792}. Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) and T-cells. Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod. Present at regions of cell-cell contacts but also at the leading edge of migrating cells.
Disease Associations
Tissue Specificity Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-derived dendritic cells (MDDC) (at protein level). Highly expressed in lymph nodes and spleen. Expressed in antigen-presenting cells. Faintly expressed in the majority of nonimmune system tissues. {ECO:0000269PubMed:21930792}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0001772 immunological synapse
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031256 leading edge membrane
GO:0031259 uropod membrane
GO:0097197 tetraspanin-enriched microdomain
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UWF3
PhosphoSite PhosphoSite-Q6UWF3
TrEMBL
UniProt Splice Variant
Entrez Gene 388325
UniGene Hs.462080
RefSeq XP_005256688
HUGO HGNC:33504
OMIM 614406
CCDS
HPRD 18267
IMGT
EMBL AC087500 AK057142 AK297035 AY358809 BC127925 BC130554 BC130556 BC144395 CH471108 DQ778084
GenPept AAI27926 AAI30555 AAI30557 AAI44396 AAQ89169 ABI63348 BAG59563 EAW90349 EAW90350

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca