Version 5.4
Homo sapiens Gene: SCIMP
Summary
InnateDB Gene IDBG-21257.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCIMP
Gene Name SLP adaptor and CSK interacting membrane protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161929
Encoded Proteins
IDBP-230264
chromosome 17 open reading frame 87
IDBP-764641
IDBP-764918
IDBP-757916
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:5208961-5234860
Strand Reverse strand
Band p13.2
Transcripts
ENST00000399600 ENSP00000382509
ENST00000574081 ENSP00000461269
ENST00000571800 ENSP00000459605
ENST00000574297 ENSP00000459153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0001772 immunological synapse
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031256 leading edge membrane
GO:0031259 uropod membrane
GO:0097197 tetraspanin-enriched microdomain
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057135
View Gene Order
ENSBTAG00000035975
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.462080
RefSeq NM_001271842 NM_207103 XM_005256631
HUGO
OMIM
CCDS CCDS42242 CCDS62044
HPRD 18267
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca