InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS26A

Summary

InnateDB Protein

IDBP-76511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS26A

Protein Name

vacuolar protein sorting 26 homolog A (S. pombe)

Synonyms

HB58; Hbeta58; PEP8A; VPS26;

Species

Homo sapiens

Ensembl Protein

ENSP00000263559

InnateDB Gene

IDBG-76507 (VPS26A)

Protein Structure

UniProt Annotation

Function

Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). {ECO:0000269PubMed:15247922, ECO:0000269PubMed:16407403}.

Subcellular Localization

Cytoplasm. Endosome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	63 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0015031	protein transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005768	endosome
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0031982	vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome