Version 5.4
Homo sapiens Protein: LSM4
Summary
InnateDB Protein IDBP-765124.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSM4
Protein Name
Synonyms GRP; YER112W;
Species Homo sapiens
Ensembl Protein ENSP00000469468
InnateDB Gene IDBG-37991 (LSM4)
Protein Structure
UniProt Annotation
Function Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
Experimentally validated
Total 60 [view]
Protein-Protein 57 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Cellular Component
GO:0005681 spliceosomal complex
GO:0005688 U6 snRNP
GO:0005829 cytosol
GO:0030532 small nuclear ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain
PFAM PF01423
PRINTS
PIRSF
SMART SM00651
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y4Z0
PhosphoSite PhosphoSite-Q9Y4Z0
TrEMBL U3KQK1
UniProt Splice Variant
Entrez Gene 25804
UniGene Hs.515255
RefSeq NP_036453
HUGO HGNC:17259
OMIM 607284
CCDS CCDS12374
HPRD 06284
IMGT
EMBL AC008397 AF117235 AF182290 AF251218 AJ238096 BC000387 BC003652 BC022198 BC023665
GenPept AAD56228 AAF17216 AAF90055 AAH00387 AAH03652 AAH22198 AAH23665 CAB45867

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca