Version 5.4
Homo sapiens Gene: LSM4
Summary
InnateDB Gene IDBG-37991.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSM4
Gene Name LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Synonyms GRP; YER112W
Species Homo sapiens
Ensembl Gene ENSG00000130520
Encoded Proteins
IDBP-810885
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
IDBP-765693
IDBP-810889
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
IDBP-765124
IDBP-810891
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3\'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:18306230-18323274
Strand Reverse strand
Band p13.11
Transcripts
ENST00000252816 ENSP00000475950
ENST00000600289 ENSP00000469028
ENST00000593564
ENST00000594828 ENSP00000477443
ENST00000593829 ENSP00000469468
ENST00000597776 ENSP00000476184
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
Experimentally validated
Total 60 [view]
Protein-Protein 57 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Cellular Component
GO:0005681 spliceosomal complex
GO:0005688 U6 snRNP
GO:0005829 cytosol
GO:0030532 small nuclear ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031848
View Gene Order
ENSBTAG00000008578
Not yet available
Pathways
NETPATH
REACTOME
REACT_20518
mRNA decay by 5' to 3' exoribonuclease pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515255
RefSeq NM_001252129 NM_012321
HUGO
OMIM
CCDS CCDS12374 CCDS62601
HPRD 06284
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca