InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOC2

Summary

InnateDB Protein

IDBP-765384.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOC2

Protein Name

Synonyms

APO-CII; APOC-II;

Species

Homo sapiens

Ensembl Protein

ENSP00000466775

InnateDB Gene

IDBG-306903 (APOC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008047	enzyme activator activity
GO:0008289	lipid binding
GO:0016004	phospholipase activator activity
GO:0042803	protein homodimerization activity
GO:0043274	phospholipase binding
GO:0055102	lipase inhibitor activity
GO:0060230	lipoprotein lipase activator activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0006629	lipid metabolic process
GO:0006869	lipid transport
GO:0007603	phototransduction, visible light
GO:0010518	positive regulation of phospholipase activity
GO:0010898	positive regulation of triglyceride catabolic process
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0016042	lipid catabolic process
GO:0032375	negative regulation of cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034370	triglyceride-rich lipoprotein particle remodeling
GO:0034371	chylomicron remodeling
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0034382	chylomicron remnant clearance
GO:0034384	high-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0043085	positive regulation of catalytic activity
GO:0043086	negative regulation of catalytic activity
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0060697	positive regulation of phospholipid catabolic process
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome