InnateDB Protein
|
IDBP-7656.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CTSB
|
Protein Name
|
cathepsin B
|
Synonyms
|
APPS; CPSB;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000345672
|
InnateDB Gene
|
IDBG-7654 (CTSB)
|
Protein Structure
|
|
Function |
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
|
Subcellular Localization |
Lysosome. Melanosome. Secreted, extracellular space {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
47
[view]
|
Protein-Protein |
47
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000668
Peptidase C1A, papain C-terminal
IPR012599
Peptidase C1A, propeptide
|
PFAM |
PF00112
PF08127
|
PRINTS |
PR00705
|
PIRSF |
|
SMART |
SM00645
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P07858
|
PhosphoSite |
PhosphoSite-P07858
|
TrEMBL |
R4GMQ5
|
UniProt Splice Variant |
|
Entrez Gene |
1508
|
UniGene |
Hs.520898
|
RefSeq |
NP_001899
|
HUGO |
HGNC:2527
|
OMIM |
116810
|
CCDS |
CCDS5986
|
HPRD |
00287
|
IMGT |
|
EMBL |
AC025857
AC069185
AK075393
AK092070
AY082426
AY082427
BC010240
BC095408
CH471157
L16510
M13230
M14221
|
GenPept |
AAA52125
AAA52129
AAC37547
AAH10240
AAH95408
AAL99368
AAL99369
BAG52127
BAG52477
EAW65630
EAW65632
EAW65633
EAW65634
EAW65635
EAW65636
|
|
|