Version 5.4
Homo sapiens Protein: TYROBP
Summary
InnateDB Protein IDBP-765815.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYROBP
Protein Name
Synonyms DAP12; KARAP; PLOSL;
Species Homo sapiens
Ensembl Protein ENSP00000468447
InnateDB Gene IDBG-46035 (TYROBP)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43914
PhosphoSite PhosphoSite-O43914
TrEMBL
UniProt Splice Variant
Entrez Gene 7305
UniGene Hs.515369
RefSeq NP_937758
HUGO HGNC:12449
OMIM 604142
CCDS CCDS46058
HPRD 04996
IMGT
EMBL AD000833 AD000864 AF019562 AF019563 AJ010098 AK290385 AY074782 BC011175 BP295666 BT009851 CR450342 CR542202
GenPept AAD09436 AAD09437 AAH11175 AAL74017 AAP88853 BAF83074 CAB52288 CAG29338 CAG46999

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca