InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HDAC8

Summary

InnateDB Protein

IDBP-76729.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC8

Protein Name

histone deacetylase 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362660

InnateDB Gene

IDBG-76713 (HDAC8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	96 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	60 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004407	histone deacetylase activity
GO:0008134	transcription factor binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046872	metal ion binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0006333	chromatin assembly or disassembly
GO:0006351	transcription, DNA-templated
GO:0007062	sister chromatid cohesion
GO:0016568	chromatin modification
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0071922	regulation of cohesin localization to chromatin