Version 5.4
Homo sapiens Gene: HDAC8
Summary
InnateDB Gene IDBG-76713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC8
Gene Name histone deacetylase 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147099
Encoded Proteins
IDBP-76715
histone deacetylase 8
IDBP-76717
histone deacetylase 8
IDBP-76719
histone deacetylase 8
IDBP-76721
histone deacetylase 8
IDBP-76723
histone deacetylase 8
IDBP-76727
histone deacetylase 8
IDBP-76729
histone deacetylase 8
IDBP-76731
histone deacetylase 8
IDBP-76733
histone deacetylase 8
IDBP-375827
histone deacetylase 8
IDBP-375830
histone deacetylase 8
IDBP-375836
histone deacetylase 8
IDBP-375844
histone deacetylase 8
IDBP-375846
histone deacetylase 8
IDBP-375860
histone deacetylase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:72329516-72573103
Strand Reverse strand
Band q13.1
Transcripts
ENST00000373589 ENSP00000362691
ENST00000373583 ENSP00000362685
ENST00000373573 ENSP00000362674
ENST00000373571 ENSP00000362672
ENST00000373568 ENSP00000362669
ENST00000373560 ENSP00000362661
ENST00000373559 ENSP00000362660
ENST00000373556 ENSP00000362657
ENST00000373554 ENSP00000362655
ENST00000436675 ENSP00000416489
ENST00000415409 ENSP00000396424
ENST00000412342 ENSP00000400180
ENST00000439122 ENSP00000414486
ENST00000421523 ENSP00000398997
ENST00000444609 ENSP00000409778
ENST00000470998
ENST00000478743
ENST00000486704
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 96 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 60 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004407 histone deacetylase activity
GO:0008134 transcription factor binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046872 metal ion binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0006333 chromatin assembly or disassembly
GO:0006351 transcription, DNA-templated
GO:0007062 sister chromatid cohesion
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071922 regulation of cohesin localization to chromatin
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000228 nuclear chromosome
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067567
View Gene Order
ENSBTAG00000046092
Not yet available
Pathways
NETPATH
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_172623
Chromatin organization pathway
REACT_299
Signaling by NOTCH pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
TGF-beta signaling pathway
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.310536 Hs.609335 Hs.610708
RefSeq NM_001166418 NM_001166419 NM_001166420 NM_001166422 NM_001166448 NM_018486
HUGO
OMIM
CCDS CCDS14420 CCDS55448 CCDS55449 CCDS55450 CCDS55451 CCDS55452
HPRD 02227
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca