InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BARX1

Summary

InnateDB Protein

IDBP-76804.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BARX1

Protein Name

BARX homeobox 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000253968

InnateDB Gene

IDBG-76800 (BARX1)

Protein Structure

UniProt Annotation

Function

Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter. {ECO:0000250, ECO:0000269PubMed:9804553}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at higher levels in testis and heart. Detected in craniofacial tissue and adult iris, but not in lymphocytes, fibroblasts, choroid retina, retinal pigment epithelium, kidney, or fetal liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007267	cell-cell signaling
GO:0009888	tissue development
GO:0009952	anterior/posterior pattern specification
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030855	epithelial cell differentiation
GO:0048513	organ development
GO:0048536	spleen development
GO:0048856	anatomical structure development
GO:0055123	digestive system development