InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCKAP1

Summary

InnateDB Protein

IDBP-76905.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCKAP1

Protein Name

NCK-associated protein 1

Synonyms

HEM2; NAP1; NAP125; p125Nap1;

Species

Homo sapiens

Ensembl Protein

ENSP00000354251

InnateDB Gene

IDBG-76903 (NCKAP1)

Protein Structure

UniProt Annotation

Function

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0006915	apoptotic process
GO:0007354	zygotic determination of anterior/posterior axis, embryo
GO:0007417	central nervous system development
GO:0007492	endoderm development
GO:0008078	mesodermal cell migration
GO:0010172	embryonic body morphogenesis
GO:0010592	positive regulation of lamellipodium assembly
GO:0016601	Rac protein signal transduction
GO:0030032	lamellipodium assembly
GO:0030903	notochord development
GO:0030950	establishment or maintenance of actin cytoskeleton polarity
GO:0032880	regulation of protein localization
GO:0035050	embryonic heart tube development
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042074	cell migration involved in gastrulation
GO:0045087	innate immune response
GO:0045175	basal protein localization
GO:0045176	apical protein localization
GO:0048339	paraxial mesoderm development
GO:0048340	paraxial mesoderm morphogenesis
GO:0048570	notochord morphogenesis
GO:0048617	embryonic foregut morphogenesis
GO:0050821	protein stabilization
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation

Cellular Component

GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0031209	SCAR complex
GO:0031258	lamellipodium membrane
GO:0070062	extracellular vesicular exosome