InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NCKAP1

Summary

InnateDB Gene

IDBG-76903.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCKAP1

Gene Name

NCK-associated protein 1

Synonyms

HEM2; NAP1; NAP125; p125Nap1

Species

Homo sapiens

Ensembl Gene

ENSG00000061676

Encoded Proteins

IDBP-76905

NCK-associated protein 1

IDBP-76907

NCK-associated protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:182909115-183038858

Strand

Reverse strand

Band

q32.1

Transcripts

ENST00000360982	ENSP00000354251
ENST00000361354	ENSP00000355348
ENST00000477988
ENST00000478449
ENST00000471640
ENST00000492058
ENST00000493359
ENST00000495619

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0006915	apoptotic process
GO:0007354	zygotic determination of anterior/posterior axis, embryo
GO:0007417	central nervous system development
GO:0007492	endoderm development
GO:0008078	mesodermal cell migration
GO:0010172	embryonic body morphogenesis
GO:0010592	positive regulation of lamellipodium assembly
GO:0016601	Rac protein signal transduction
GO:0030032	lamellipodium assembly
GO:0030903	notochord development
GO:0030950	establishment or maintenance of actin cytoskeleton polarity
GO:0032880	regulation of protein localization
GO:0035050	embryonic heart tube development
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042074	cell migration involved in gastrulation
GO:0045087	innate immune response
GO:0045175	basal protein localization
GO:0045176	apical protein localization
GO:0048339	paraxial mesoderm development
GO:0048340	paraxial mesoderm morphogenesis
GO:0048570	notochord morphogenesis
GO:0048617	embryonic foregut morphogenesis
GO:0050821	protein stabilization
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation

Cellular Component

GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0031209	SCAR complex
GO:0031258	lamellipodium membrane
GO:0070062	extracellular vesicular exosome