InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP19

Summary

InnateDB Protein

IDBP-76935.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP19

Protein Name

dual specificity phosphatase 19

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343905

InnateDB Gene

IDBG-76931 (DUSP19)

Protein Structure

UniProt Annotation

Function

Has a dual specificity toward Ser/Thr and Tyr-containing proteins. {ECO:0000269PubMed:12479873}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest. {ECO:0000269PubMed:12479873}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0004860	protein kinase inhibitor activity
GO:0005078	MAP-kinase scaffold activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0008579	JUN kinase phosphatase activity
GO:0016791	phosphatase activity
GO:0030295	protein kinase activator activity
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0006470	protein dephosphorylation
GO:0007254	JNK cascade
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0043410	positive regulation of MAPK cascade
GO:0043507	positive regulation of JUN kinase activity
GO:0043508	negative regulation of JUN kinase activity
GO:0045860	positive regulation of protein kinase activity
GO:0046329	negative regulation of JNK cascade
GO:0046330	positive regulation of JNK cascade

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782

PRINTS

PIRSF

SMART

SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8WTR2