InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YWHAB

Summary

InnateDB Protein

IDBP-76946.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YWHAB

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Synonyms

GW128; HEL-S-1; HS1; KCIP-1; YWHAA;

Species

Homo sapiens

Ensembl Protein

ENSP00000300161

InnateDB Gene

IDBG-76944 (YWHAB)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. {ECO:0000269PubMed:17717073, ECO:0000269PubMed:19592491}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 442 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	442 [view]
Protein-Protein	439 [view]
Protein-DNA	1 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0042826	histone deacetylase binding
GO:0050815	phosphoserine binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006915	apoptotic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0007411	axon guidance
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0035308	negative regulation of protein dephosphorylation
GO:0035329	hippo signaling
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043085	positive regulation of catalytic activity
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051220	cytoplasmic sequestering of protein
GO:0061024	membrane organization
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0042470	melanosome
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome