InnateDB Protein
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IDBP-76948.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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YWHAB
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Protein Name
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tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
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Synonyms
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GW128; HEL-S-1; HS1; KCIP-1; YWHAA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000361930
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InnateDB Gene
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IDBG-76944 (YWHAB)
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Protein Structure
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Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. {ECO:0000269PubMed:17717073, ECO:0000269PubMed:19592491}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 442 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated |
Total |
442
[view]
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Protein-Protein |
439
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
2
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
30 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000308
14-3-3 protein
IPR023410
14-3-3 domain
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PFAM |
PF00244
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PRINTS |
PR00305
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PIRSF |
PIRSF000868
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SMART |
SM00101
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TIGRFAMs |
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Modification |
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SwissProt |
P31946
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PhosphoSite |
PhosphoSite-P31946
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TrEMBL |
V9HWD6
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UniProt Splice Variant |
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Entrez Gene |
7529
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UniGene |
Hs.713768
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RefSeq |
NP_003395
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HUGO |
HGNC:12849
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OMIM |
601289
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CCDS |
CCDS13339
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HPRD |
03184
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IMGT |
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EMBL |
AK292717
AL008725
BC001359
CH471077
EU794580
X57346
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GenPept |
AAH01359
ACJ13634
BAF85406
CAA15497
CAA40621
EAW75893
EAW75894
EAW75896
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