InnateDB Protein
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IDBP-77066.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NEUROG3
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Protein Name
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neurogenin 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000242462
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InnateDB Gene
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IDBG-77064 (NEUROG3)
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Protein Structure
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Function |
Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
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Disease Associations |
Diarrhea 4, malabsorptive, congenital (DIAR4) [MIM:610370]: A disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. {ECO:0000269PubMed:16855267}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001047
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core promoter binding
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003690
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double-stranded DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003713
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transcription coactivator activity
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GO:0031490
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chromatin DNA binding
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GO:0046983
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protein dimerization activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0007275
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multicellular organismal development
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GO:0007399
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nervous system development
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GO:0007417
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central nervous system development
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GO:0007422
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peripheral nervous system development
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GO:0021510
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spinal cord development
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GO:0030855
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epithelial cell differentiation
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GO:0030900
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forebrain development
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GO:0030902
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hindbrain development
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GO:0031018
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endocrine pancreas development
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GO:0045597
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positive regulation of cell differentiation
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GO:0045666
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positive regulation of neuron differentiation
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048814
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regulation of dendrite morphogenesis
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GO:0051091
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positive regulation of sequence-specific DNA binding transcription factor activity
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GO:0060290
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transdifferentiation
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y4Z2
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PhosphoSite |
PhosphoSite-Q9Y4Z2
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TrEMBL |
E0X9P2
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UniProt Splice Variant |
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Entrez Gene |
50674
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UniGene |
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RefSeq |
NP_066279
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HUGO |
HGNC:13806
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OMIM |
604882
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CCDS |
CCDS31212
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HPRD |
05346
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IMGT |
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EMBL |
AF234829
AJ133776
AK313952
AL450311
BC074938
BC074939
BC117488
BC126468
CH471083
GQ904714
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GenPept |
AAH74938
AAH74939
AAI17489
AAI26469
AAK15022
ADM86144
BAG36669
CAB45384
CAH72729
EAW54328
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