InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NEUROG3

Summary

InnateDB Gene

IDBG-77064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEUROG3

Gene Name

neurogenin 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000122859

Encoded Proteins

IDBP-77066

neurogenin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:69571698-69573238

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000242462

ENSP00000242462

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0031490	chromatin DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0007417	central nervous system development
GO:0007422	peripheral nervous system development
GO:0021510	spinal cord development
GO:0030855	epithelial cell differentiation
GO:0030900	forebrain development
GO:0030902	hindbrain development
GO:0031018	endocrine pancreas development
GO:0045597	positive regulation of cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048814	regulation of dendrite morphogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060290	transdifferentiation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000044312

View Gene Order

ENSBTAG00000006431

Not yet available

Pathways

NETPATH

REACTOME

REACT_13650

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway

REACT_13673

Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway

REACT_111045

Developmental Biology pathway

REACT_13698

Regulation of beta-cell development pathway

KEGG

hsa04950

Maturity onset diabetes of the young pathway

INOH

PID NCI

hes_heypathway

Notch-mediated HES/HEY network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_020999

HUGO

OMIM

CCDS

CCDS31212

HPRD

05346

IMGT

EMBL

GenPept

RNA Seq Atlas