InnateDB Protein
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IDBP-77114.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COL13A1
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Protein Name
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collagen, type XIII, alpha 1
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Synonyms
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COLXIIIA1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000350463
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InnateDB Gene
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IDBG-77110 (COL13A1)
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Protein Structure
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Function |
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. {ECO:0000250UniProtKB:Q9R1N9, ECO:0000269PubMed:10865988, ECO:0000269PubMed:11956183}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:11013208}; Single-pass type II membrane protein {ECO:0000250UniProtKB:Q9R1N9, ECO:0000269PubMed:11013208}.
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Disease Associations |
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Tissue Specificity |
Widely expressed in both fetal and adult ocular tissues (at protein level). In the eye, expression is accentuated in the ciliary muscle, optic nerve and the neural retina. In early placenta, localized to fibroblastoid stromal cells of the placental villi, to endothelial cells of developing capillaries and to cells of the cytotrophoblastic columns. Also detected in large decidual cells of the decidual membrane and to stromal cells of the gestational endometrium, but not in the epithelial cells in the endometrial glands. {ECO:0000269PubMed:10865988, ECO:0000269PubMed:8246446}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008160
Collagen triple helix repeat
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PFAM |
PF01391
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5TAT6
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PhosphoSite |
PhosphoSite-Q5TAT6
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TrEMBL |
Q9UP45
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UniProt Splice Variant |
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Entrez Gene |
1305
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UniGene |
Hs.695934
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RefSeq |
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HUGO |
HGNC:2190
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OMIM |
120350
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CCDS |
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HPRD |
00383
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IMGT |
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EMBL |
AC024601
AC025426
AF071009
AJ293624
AL138925
BC136385
M15524
M20795
M20796
M20797
M20798
M20799
M20800
M20801
M20802
M20803
M20804
M20805
M33653
M59217
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GenPept |
AAA51685
AAA51987
AAA51988
AAA51989
AAA51990
AAA51991
AAA52047
AAA52048
AAD48082
AAI36386
CAC00688
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