Version 5.4
Homo sapiens Protein: GULP1
Summary
InnateDB Protein IDBP-77176.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GULP1
Protein Name GULP, engulfment adaptor PTB domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000352047
InnateDB Gene IDBG-77174 (GULP1)
Protein Structure
UniProt Annotation
Function May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269PubMed:10574763, ECO:0000269PubMed:10574771, ECO:0000269PubMed:16497666, ECO:0000269PubMed:17398097}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16497666}. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.
Disease Associations
Tissue Specificity Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary. {ECO:0000269PubMed:10574763}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0006869 lipid transport
GO:0006911 phagocytosis, engulfment
GO:0006915 apoptotic process
GO:0007165 signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain
PFAM PF00640
PF14719
PF08416
PRINTS
PIRSF
SMART SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBP9
PhosphoSite PhosphoSite-Q9UBP9
TrEMBL B8ZZL1
UniProt Splice Variant
Entrez Gene 51454
UniGene Hs.712910
RefSeq XP_006712651
HUGO HGNC:18649
OMIM 608165
CCDS CCDS2295
HPRD 12181
IMGT
EMBL AC092598 AC104131 AC108493 AC125490 AC133606 AF191771 AF200715 AK055718 AK298626 AK314498 BC001103 CH471058
GenPept AAF08006 AAF18975 AAH01103 AAX93242 AAY24122 BAG37098 BAG60802 EAX10913 EAX10914 EAX10915 EAX10917

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca