InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU5F1

Summary

InnateDB Protein

IDBP-77212.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU5F1

Protein Name

POU class 5 homeobox 1

Synonyms

Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4;

Species

Homo sapiens

Ensembl Protein

ENSP00000259915

InnateDB Gene

IDBG-77210 (POU5F1)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269PubMed:18035408}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern.

Disease Associations

Tissue Specificity

Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. {ECO:0000269PubMed:1408763, ECO:0000269PubMed:7908264}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 315 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	40 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	315 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031625	ubiquitin protein ligase binding
GO:0035198	miRNA binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001714	endodermal cell fate specification
GO:0001824	blastocyst development
GO:0003130	BMP signaling pathway involved in heart induction
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0009611	response to wounding
GO:0009653	anatomical structure morphogenesis
GO:0009786	regulation of asymmetric cell division
GO:0010468	regulation of gene expression
GO:0035019	somatic stem cell maintenance
GO:0035413	positive regulation of catenin import into nucleus
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0060795	cell fate commitment involved in formation of primary germ layer
GO:0060913	cardiac cell fate determination
GO:0060965	negative regulation of gene silencing by miRNA
GO:0090081	regulation of heart induction by regulation of canonical Wnt receptor signaling pathway
GO:0090308	regulation of methylation-dependent chromatin silencing