Homo sapiens Protein: AIFM2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-77224.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | AIFM2 | ||||||||||||||||||
Protein Name | apoptosis-inducing factor, mitochondrion-associated, 2 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000312370 | ||||||||||||||||||
InnateDB Gene | IDBG-77220 (AIFM2) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. {ECO:0000269PubMed:11980907, ECO:0000269PubMed:12135761, ECO:0000269PubMed:15958387}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm. Mitochondrion outer membrane. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells. {ECO:0000269PubMed:12135761}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000103
Pyridine nucleotide-disulphide oxidoreductase, class-II IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain IPR003042 Aromatic-ring hydroxylase-like IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain |
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PFAM |
PF00070
PF07992 |
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PRINTS |
PR00469
PR00420 PR00368 |
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PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9BRQ8 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9BRQ8 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 84883 | ||||||||||||||||||
UniGene | Hs.682313 | ||||||||||||||||||
RefSeq | NP_116186 | ||||||||||||||||||
HUGO | HGNC:21411 | ||||||||||||||||||
OMIM | 605159 | ||||||||||||||||||
CCDS | CCDS7297 | ||||||||||||||||||
HPRD | 09797 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF337957 AF506757 AK027403 AK127353 AL731540 BC006121 BC023601 BX537621 CH471083 | ||||||||||||||||||
GenPept | AAH06121 AAH23601 AAL73229 AAM77596 BAB55089 BAG54492 CAH56481 CAI13684 EAW54376 | ||||||||||||||||||