Version 5.4
Homo sapiens Protein: PPA1
Summary
InnateDB Protein IDBP-77336.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPA1
Protein Name pyrophosphatase (inorganic) 1
Synonyms HEL-S-66p; IOPPP; PP; PP1; SID6-8061;
Species Homo sapiens
Ensembl Protein ENSP00000362329
InnateDB Gene IDBG-77334 (PPA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed ubiquitously. {ECO:0000269PubMed:10542310}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphatase activity
GO:0016462 pyrophosphatase activity
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006796 phosphate-containing compound metabolic process
GO:0010467 gene expression
GO:0071344 diphosphate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR008162 Inorganic pyrophosphatase
PFAM PF00719
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15181
PhosphoSite PhosphoSite-Q15181
TrEMBL V9HWB5
UniProt Splice Variant
Entrez Gene 5464
UniGene
RefSeq NP_066952
HUGO HGNC:9226
OMIM 179030
CCDS CCDS7299
HPRD 01527
IMGT
EMBL AB026723 AF092439 AF108211 AF119665 AF154065 AF217186 AL731540 BC001022 BC061581 BC105034 BC105036 BC107882 CH471083 EU794626 Z48605
GenPept AAD24964 AAD34643 AAF17222 AAG36780 AAH01022 AAH61581 AAI05035 AAI05037 AAI07883 AAP97214 ACJ13680 BAA84702 CAA88494 CAI13692 EAW54383 EAW54386

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca