Version 5.4
Homo sapiens Gene: PPA1
Summary
InnateDB Gene IDBG-77334.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPA1
Gene Name pyrophosphatase (inorganic) 1
Synonyms HEL-S-66p; IOPPP; PP; PP1; SID6-8061
Species Homo sapiens
Ensembl Gene ENSG00000180817
Encoded Proteins
IDBP-77336
pyrophosphatase (inorganic) 1
IDBP-77338
pyrophosphatase (inorganic) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:70202830-70233911
Strand Reverse strand
Band q22.1
Transcripts
ENST00000373232 ENSP00000362329
ENST00000373230 ENSP00000362327
ENST00000460755
ENST00000495346
ENST00000610026
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphatase activity
GO:0016462 pyrophosphatase activity
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006796 phosphate-containing compound metabolic process
GO:0010467 gene expression
GO:0071344 diphosphate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020089
View Gene Order
ENSBTAG00000007836
Not yet available
Pathways
NETPATH
REACTOME
REACT_15306
Cytosolic tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00190
Oxidative phosphorylation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_021129
HUGO
OMIM
CCDS CCDS7299
HPRD 01527
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca