Version 5.4
Homo sapiens Protein: MFSD10
Summary
InnateDB Protein IDBP-7741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFSD10
Protein Name major facilitator superfamily domain containing 10
Synonyms TETRAN; TETTRAN;
Species Homo sapiens
Ensembl Protein ENSP00000332646
InnateDB Gene IDBG-7739 (MFSD10)
Protein Structure
UniProt Annotation
Function Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump. {ECO:0000269PubMed:17362938}.
Subcellular Localization Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008493 tetracycline transporter activity
Biological Process
GO:0006810 transport
GO:0006915 apoptotic process
GO:0015904 tetracycline transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14728
PhosphoSite PhosphoSite-Q14728
TrEMBL
UniProt Splice Variant
Entrez Gene 10227
UniGene Hs.632581
RefSeq NP_001111
HUGO HGNC:16894
OMIM 610977
CCDS CCDS3365
HPRD 10265
IMGT
EMBL AL390065 BC001502 BC014979 CH471131 L11669
GenPept AAA36729 AAH01502 AAH14979 CAM21300 EAW82496

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca