InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAGEE1

Summary

InnateDB Protein

IDBP-77494.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAGEE1

Protein Name

melanoma antigen family E, 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354912

InnateDB Gene

IDBG-77492 (MAGEE1)

Protein Structure

UniProt Annotation

Function

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269PubMed:20864041}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016010	dystrophin-associated glycoprotein complex
GO:0030425	dendrite
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm