InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UNC5B

Summary

InnateDB Protein

IDBP-77564.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UNC5B

Protein Name

unc-5 homolog B (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000334329

InnateDB Gene

IDBG-77562 (UNC5B)

Protein Structure

UniProt Annotation

Function

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. {ECO:0000269PubMed:12598906, ECO:0000269PubMed:15729359}.

Subcellular Localization

Membrane {ECO:0000269PubMed:18582460}; Single-pass type I membrane protein {ECO:0000269PubMed:18582460}. Note=Associated with lipid raft.

Disease Associations

Tissue Specificity

Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. {ECO:0000269PubMed:12359238}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0033564	anterior/posterior axon guidance
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000488 Death domain
IPR000884 Thrombospondin, type 1 repeat
IPR000906 ZU5 domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011029 Death-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF00531
PF00090
PF00791
PF07679

PRINTS

PIRSF

SMART

SM00005
SM00209
SM00218
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IZJ1