Version 5.4
Homo sapiens Gene: UNC5B
Summary
InnateDB Gene IDBG-77562.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC5B
Gene Name unc-5 homolog B (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000107731
Encoded Proteins
IDBP-77564
unc-5 homolog B (C. elegans)
IDBP-77566
unc-5 homolog B (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:71212570-71302864
Strand Forward strand
Band q22.1
Transcripts
ENST00000335350 ENSP00000334329
ENST00000373192 ENSP00000362288
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0033564 anterior/posterior axon guidance
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020099
View Gene Order
ENSBTAG00000014270
Not yet available
Pathways
NETPATH
REACTOME
REACT_22128
Role of DCC in regulating apoptosis pathway
REACT_22384
Netrin mediated repulsion signals pathway
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_578
Apoptosis pathway
REACT_13648
Regulation of Apoptosis pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
netrin_pathway
Netrin-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.522997
RefSeq NM_001244889 NM_170744
HUGO
OMIM
CCDS CCDS58083 CCDS7309
HPRD 08487
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca